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. 2022 Mar 22;12:4832. doi: 10.1038/s41598-022-08974-8

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Example images of biopsy samples. Multiple cortexes are combined in each case. To reduce the color and intensity variations present in the stained images, we computed the global mean and standard deviation of each channel in the Lab color space for the Reinhard color normalization for all data and used them as reference values to normalize our data. The figure shows Reinhard color normalization before (left) and after (right).