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. 2021 Dec 21;15:15–28. doi: 10.1016/j.bioactmat.2021.12.020

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 5 — In vivo trafficking of NP/mDs. (a) Time-dependent Pt profiles in the blood after an i.v. dose of OXA, PO12 NPs, and NP/mDs to SD rats, n = 3. (b) Time-lapse NIR fluorescent imaging of BALB/c mice bearing CT26 syngeneic tumors after an i.v. injection of free DiR, DiR-PO12 NPs, and DiR-NP/mDs, n = 3. (c) Ex vivo NIR imaging of resected organs, tumors, and plasma. (d) The quantitative biodistribution analysis based on the total NIR signals. (e) The co-localization of free DiR, DiR-PO12 NPs, and DiR-NP/mDs in liver and tumor with microvessels stained with CD31 antibody and nuclei stained with DAPI. Scale bar = 100 μm. Data points in a and d represent mean ± SD. Statistical significance was calculated by ANOVA with Tukey's test. n.s., not significant, *p < 0.05, **p < 0.01, and ***p < 0.001.