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. 2022 Feb 15;298(4):101729. doi: 10.1016/j.jbc.2022.101729

Figure 4.

Figure 4

MFA in βTC3 G6pc2 WT and KO cells shows increased absolute flux through glycolytic and mitochondrial pathways.A, flux network representing oxidative βTC3 metabolism constructed in INCA (58, 59). Measured media metabolites are shown in blue while measured intracellular metabolites are highlighted in green. B, absolute extra- and intracellular fluxes in G6pc2 WT and KO βTC3 cells at 5 mM glucose concentration estimated using MFA. Data represent means ± SEM, ∗p < 0.05 (n = 3). C, absolute extra- and intracellular fluxes in G6pc2 WT and KO βTC3 cells at 11 mM glucose concentration estimated using MFA. Data represent means ± SEM, ∗p < 0.05 (n = 3). KO, knockout; MFA, metabolic flux analysis.