Fig. 5.

Dynamic, stage-stratified histone modification cross talk in P. falciparum parasites. Interplay scores between bivalent posttranslational modifications occurring in (A) trophozoites, (B) immature gametocytes, and (C) mature stage gametocytes where the color intensity of the square is proportional to the interplay score. Ring plots indicate top and bottom 10 bivalent combinations, where the color of the edges is proportional to the interplay score shown in the heatmap. Interplay scores for trophozoites include the unique 4% and the overlapping 6% with immature gametocytes (I_GC) and 1% with mature gametocytes (M_GC). Interplay scores for immature gametocytes include the unique 25% and the overlapping 6% with trophozoites and 25% with mature gametocytes. Interplay scores for mature gametocytes include the unique 6% and the overlapping 4% with trophozoites and 25% with immature gametocytes.