Table 2.
Univariate analysis of patients with detection of HSV-infection in bronchoalveolar lavage. Results above 500 Geq/ml were considered positive.
| Yes (n=61) | No (n=73) | p | |
|---|---|---|---|
| Age (median [IQR]) | 73 [61 to 78] | 72 [57 to 79] | 0.590 |
| Sex = male (%) | 47 (77.0) | 51 (69.9) | 0.460 |
| BMI (median [IQR]) | 27.2 [24.5 to 31.3] | 25.8 [23.1 to 29.6] | 0.151 |
| SOFA (median [IQR]) | 7 [4 to 10] | 6 [3 to 11] | 0.655 |
| LOS ICU (median [IQR]) | 24 [16 to 43] | 13 [6 to 20] | <0.001 |
| Duration of mechanical ventilation (in hours) (median [IQR]) | 417.0 [267.0 to 767.0] | 214.0 [85.0 to 407.0] | <0.001 |
| LOS hospital (median [IQR]) | 37 [23 to 47] | 19 [12 to 33] | <0.001 |
| ICU mortality (yes, %) | 35 (57.4) | 33 (45.2) | 0.219 |
| History of immunosuppression (yes, %) | 17 (27.9) | 17 (23.3) | 0.561 |
| Therapy with dexamethasone (yes, %) | 39 (63.9) | 41 (56.2) | 0.462 |
| Inflammation parameters at ICU admission | |||
| Baseline procalcitonin (median [IQR]) | 0.50 [0.20 to 1.88] | 0.30 [0.20 to 0.62] | 0.005 |
| Baseline CRP (median [IQR]) | 18.15 [10.28 to 24.23] | 12.60 [4.70 to 17.90] | 0.001 |
| Baseline IL-6 (median [IQR]) | 109.0 [56.0 to 246.0] | 119.0 [47.90 to 202.0] | 0.984 |
| Baseline leukocytes (median [IQR]) | 10.04 [7.12 to 13.70] | 8.38 [6.02 to 10.74] | 0.031 |
| Admission during September 2020 and January 2021of Covid-19 (%) | 41 (67.2) | 45 (61.6) | 0.625 |
BMI, body mass index; SOFA, sequential organ failure assessment; LOS, length of stay; ICU, intensive care unit; CRP, C-reactive protein in mg/dl; IL-6, interleukin 6 in ng/ml; CMV, Cytomegalovirus (was considered positive above 1250 Geq/ml); COPD, chronic obstructive pulmonary disease.