Table 3. Association of Physical Activity With Baseline Level of Global Cognitive Function Stratified by Serum NfL Concentrationa.
| Variable | β (95% CI) | Difference (95% CI) | Difference, % |
|---|---|---|---|
| Low NfLb | |||
| Low physical activityc | 0.525 (0.407 to 0.642) | 1 [Reference] | 1 [Reference] |
| Medium physical activityd | 0.476 (0.369 to 0.582) | −0.049 (−0.152 to 0.054) | 9 |
| High physical activitye | 0.509 (0.411 to 0.608) | −0.015 (−0.122 to 0.091) | 3 |
| High NfLb | |||
| Low physical activityc | 0.255 (0.083 to 0.427) | 1 [Reference] | 1 [Reference] |
| Medium physical activityd | 0.445 (0.274 to 0.617) | 0.191 (0.054 to 0.327) | 75 |
| High physical activitye | 0.366 (0.199 to 0.532) | 0.111 (−0.037 to 0.259) | 44 |
Abbreviation: NfL, neurofilament light chain.
a
All regression models were adjusted for age, race, sex, educational level, chronic conditions, and presence of the apolipoprotein E ε4 allele.
b
Serum NfL concentration: low, 25.5 pg/mL or less; high, greater than 25.5 pg/mL.
c
Participants responded to at least 4 items on the physical activity measure and reported no activity for all responses.
d
Less than 150 minutes per week.
e
At least 150 minutes per week.