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. 2022 Mar 2;25(5):150. doi: 10.3892/mmr.2022.12666

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Copyright: © Ma et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Lidocaine inhibits p38 MAPK-mediated ferroptosis in H/R-induced A549 cells. Levels of (A and B) ROS and (C) iron were detected using their corresponding commercial kits. (D) The expression levels of FTH1, GPX4 and Tf were measured via western blotting. (E) The expression levels of p-p38 and p38 were measured via western blotting. ^#P<0.05, ^##P<0.01 and ^###P<0.001 vs. H/R; ***P<0.001 vs. control. H/R, hypoxia/reoxygenation; FTH1, ferritin heavy chain 1; GPX4, glutathione peroxidase 4; Tf, transferrin; p-, phosphorylated; ROS, reactive oxygen species.