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. 2022 Mar 2;25(5):150. doi: 10.3892/mmr.2022.12666

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Copyright: © Ma et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — Lidocaine suppresses oxidative stress and the inflammatory response in H/R-induced A549 cells by blocking the p38 MAPK signaling pathway. (A) The expression levels of p-p38 and p38 were measured via western blotting. Levels of (B) IL-6, (C) IL-8 and (D) TNF-α were detected by using ELISA. The expression levels of (E) MDA, (F) SOD and (G) GSH-Px were measured. ***P<0.001 vs. control; ^ΔΔΔP<0.001 vs. H/R; ^#P<0.05 and ^###P<0.001 vs. H/R + lidocaine. H/R, hypoxia/reoxygenation; p-, phosphorylated; MDA, malondialdehyde; SOD, superoxide dismutase; GSH-Px, glutathione peroxidase.