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. 2022 Mar 2;25(5):150. doi: 10.3892/mmr.2022.12666

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Copyright: © Ma et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 6. — Lidocaine inhibits barrier dysfunction and ferroptosis in H/R-induced A549 cells by blocking the p38 MAPK signaling pathway. (A) Cell permeability was detected by performing a monolayer cell paracellular permeability assay. (B) The expression levels of ZO-1, Occludin and Claudin-1, were measured via western blotting. Levels of (C and D) ROS and (E) iron were detected by using their corresponding commercial kits. (F) The expression levels of FTH1, GPX4 and Tf were measured via western blotting. ***P<0.001 vs. control; ^ΔΔΔP<0.001 vs. H/R; ^#P<0.05, ^##P<0.01 and ^###P<0.001 vs. H/R + lidocaine. H/R, hypoxia/reoxygenation; ZO-1, zonula occludens-1; ROS, reactive oxygen species; FTH1, ferritin heavy chain 1; GPX4, glutathione peroxidase 4; Tf, transferrin.