TABLE 1.

Pharmacokinetic parameters for serum and interstitial space fluid of inflamed diabetic foot lesions and unaffected subcutaneous adipose tissue following administration of ciprofloxacin to patients with non-insulin-dependent diabetes mellitus^a

Sample	Mean ± SDb
	Cmax	Tmax	AUC0–∞, AUC0–300
Serum	2.83 ± 1.21	23 ± 8	527 ± 318, 253 ± 102
Diabetic ulcer	2.18 ± 1.13	30 ± 11	278 ± 182, 209 ± 121
Healthy subcutis	2.12 ± 0.55	23 ± 8	317 ± 207, 199 ± 75

^aPatients (n = 6) were given a single 200-mg dose i.v. over 20 min. 

^bC_max (micrograms/milliliter), maximum concentration of drug in serum; T_max (minutes), time to maximum concentration of drug in serum; AUC_0–∞ (micrograms · minute/milliliter), area under the concentration-time curve from 0 h to infinity.