Table 3.
Summary of OS and PFS by race, region, and ethnicity
| Overall | United States | RoW | |||||||
|---|---|---|---|---|---|---|---|---|---|
| n (events) | Median* (95% CI) | HR* (95% CI) | n (events) | Median* (95% CI) | HR* (95% CI) | n (events) | Median* (95% CI) | HR* (95% CI) | |
| OS | |||||||||
| Race | |||||||||
| White | 8535 (3341) | 47.8 (46.2-49.3) | Ref | 1300 (525) | 60.4 (54.7-67.7) | Ref | 7235 (2816) | 45.7 (44-47.7) | Ref |
| Black | 405 (146) | 63.4 (47.8-94.4) | 0.89 (0.75-1.05) | 311 (101) | 81.6 (63.4 to NE) | 0.82 (0.66-1.02) | 94 (45) | 34.4 (23.8-54.1) | 1.31 (0.97-1.77) |
| Asian | 693 (177) | 46 (42.3 to NE) | 0.87 (0.74-1.01) | 19 (5) | 77 (43.1 to NE) | 0.69 (0.28-1.68) | 674 (172) | 47.5 (41 to NE) | 0.87 (0.74-1.02) |
| Region | |||||||||
| United States | 1719 (663) | 64.7 (58.4-71.9) | 0.78 (0.69-0.89) | ||||||
| RoW | 8438 (3196) | 45.8 (44.1-47.7) | Ref | ||||||
| Ethnicity | |||||||||
| Not Hispanic | 7705 (2616) | 53.1 (50.1-55.6) | Ref | 1275 (467) | 71 (64.9-85.6) | Ref | 6430 (2149) | 49 (47-51.2) | Ref |
| Hispanic | 420 (137) | 58.7 (49.4-78.3) | 0.9 (0.75-1.06) | 95 (31) | 78.3 (49.4 to NE) | 0.88 (0.61-1.27) | 325 (106) | 58.3 (47.5 to NE) | 0.9 (0.74-1.1) |
| Unknown | 2032 (1106) | 36.2 (33.9-39.2) | 1.03 (0.89-1.19) | 349 (165) | 27.1 (20.7-46.4) | 1.18 (0.82-1.7) | 1683 (941) | 37 (34.9-40.3) | 0.91 (0.76-1.09) |
| PFS | |||||||||
| Race | |||||||||
| White | 8535 (4214) | 19.1 (18.4-19.6) | Ref | 1300 (726) | 24.9 (21.2-28.1) | Ref | 7235 (3488) | 18.7 (18.2-19.4) | Ref |
| Black | 405 (227) | 16.6 (12.3-20.1) | 1 (0.87-1.16) | 311 (182) | 17.8 (12.9-21.2) | 1.02 (0.86-1.21) | 94 (45) | 12.3 (9.3-23.1) | 1.15 (0.86-1.55) |
| Asian | 693 (299) | 18.1 (16.6-20) | 1 (0.89-1.13) | 19 (15) | 8.9 (5.4 to NE) | 1.75 (1.02-2.99) | 674 (284) | 18.4 (16.6-20.3) | 0.97 (0.86-1.1) |
| Region | |||||||||
| United States | 1719 (978) | 19.4 (17.3-20.5) | 0.88 (0.78-0.98) | ||||||
| RoW | 8438 (4040) | 18.5 (18-19.4) | Ref | ||||||
| Ethnicity | |||||||||
| Not Hispanic | 7705 (3712) | 20.4 (19.6-21.2) | Ref | 1275 (694) | 24.1 (20.5-27.4) | Ref | 6430 (3018) | 20 (19.3-20.8) | Ref |
| Hispanic | 420 (206) | 20.1 (17.6-23.6) | 0.98 (0.85-1.13) | 95 (51) | 22.8 (16.4-31) | 1.07 (0.81-1.43) | 325 (155) | 19.6 (15.7-23.7) | 0.96 (0.82-1.13) |
| Unknown | 2032 (1100) | 11.9 (10.8-13.1) | 1.02 (0.9-1.16) | 118 (57) | 22.5 (18.6-42.7) | 0.94 (0.68-1.3) | 1914 (1043) | 11.2 (10.3-12.5) | 1.02 (0.88-1.19) |
CI, confidence interval; HR, hazard ratio; NE, not estimable; Ref, reference group.
*
HR was based on study-stratified Cox regression analyses, adjusted for age as a covariate, whereas the median was not age adjusted.