Table 4.
Patient characteristics significantly associated with reduced HRQoL or greater fatigue by HRQoL or fatigue instrument in adults and children
| Characteristic | Adults | Children | ||||
|---|---|---|---|---|---|---|
| EQ-5D | FACT-An | PROMIS SF-7a | PedsQL 4.0 | Peds-FACIT-F | PROMIS Child SF-10a | |
| Older age | X | |||||
| Female sex | X | X | X | |||
| Non-Amish | X | X | X | X | ||
| Splenectomized | X | A | ||||
| Regularly transfused | X | X | X | |||
| Iron overload: any chelation use | X | X | X | A | ||
| Iron overload: ferritin > 1000 ng/mL | X | A | ||||
| Pulmonary hypertension | X | X | X | |||
| Nonmissense/nonmissense genotype | X | X | ||||
| Hemoglobin < 8 g/dL | X | |||||
| ≥18 total transfusions | A | |||||
A, significant only when the Amish population was excluded from analysis; X, significant in entire cohort.