Figure 1.

CHIP and mutational burden over time. Assessment of CHIP at various time points before and after CAR T-cell infusion. All mutated genes detected over time are displayed for each patient. White boxes indicate that no CHIP-associated mutation is detectable. Gray boxes indicate a CHIP-associated mutation, and the number represents the VAF. Suspected germline variants are not depicted. White boxes with a black dot represent a different next-generation sequencing panel for which not all respective targets were included. Overall survival is shown for each patient (red bar). Progression/relapse is represented by a dotted green box. Patients alive at the last follow-up are marked with black arrows. Mortality (any cause) is indicated by a black cross.