Table II.
Cox regression proportional hazards model for the analysis of the prognostic values of FOXM1 expression and PLK1 expression for overall survival in patients with hepatocellular carcinoma.
| Univariate | Multivariate | |||
|---|---|---|---|---|
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|
|
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| Characteristic | HR (95% CI) | P-value | HR (95% CI) | P-value |
| Age (continuous) | 1.01 (1.00-1.03) | 0.089 | 1.01 (0.99-1.03) | 0.292 |
| Sex (female vs. male) | 1.26 (0.88-1.80) | 0.200 | 1.08 (0.72-1.63) | 0.712 |
| Stage | ||||
| II vs. I | 1.42 (0.87-2.31) | 0.164 | 1.11 (0.66-1.88) | 0.691 |
| III–IV vs. I | 2.82 (1.86-4.28) | <0.001 | 2.00 (1.26-3.18) | 0.003 |
| Virus status (vs. none) | ||||
| HBV | 0.34 (0.20-0.56) | <0.001 | 0.43 (0.24-0.78) | 0.005 |
| HCV | 0.95 (0.56-1.61) | 0.847 | 1.15 (0.64-2.05) | 0.646 |
| HBV+HCV | 0.42 (0.10-1.74) | 0.233 | 0.37 (0.08-1.61) | 0.184 |
| FOXM1 (high vs. low) | 1.68 (1.18-2.38) | 0.004 | 1.14 (0.67-1.95) | 0.634 |
| PLK1 (high vs. low) | 2.05 (1.43-2.93) | <0.001 | 1.73 (1.00-2.99) | 0.052 |
Patients with HCC were divided into the low expression group and the high expression group at the 50th percentile. HBV, hepatitis B virus; HCV, hepatitis C virus; FOXM1, forkhead box protein M1; PLK1, polo-like kinase 1; HR, hazard ratio.