Table 2.
Adjusted odds ratios and 95% confidence intervals for incident NAFLD by SUA quartiles.
| Quartiles of serum uric acid (mg/dl) | P for trend | ||||
|---|---|---|---|---|---|
| Q1 | Q2 | Q3 | Q4 | ||
| Total | |||||
| Univariate model | Reference | 1.44 (1.24, 1.69) | 1.78 (1.52, 2.06) | 2.27 (1.96, 2.64) | <0.001 |
| Age and gender, adjusted | Reference | 1.45 (1.24, 1.70) | 1.79 (1.54, 2.08) | 2.32 (2.00, 2.70) | <0.001 |
| Multivariate model 1a | Reference | 1.32 (1.12, 1.56) | 1.44 (1.23, 1.69) | 1.72 (1.46, 2.01) | <0.001 |
| Multivariate model 2b | Reference | 1.31 (1.11, 1.55) | 1.43 (1.22, 1.69) | 1.71 (1.45, 2.01) | <0.001 |
| Male | |||||
| Univariate model | Reference | 1.35 (1.05, 1.73) | 1.45 (1.14, 1.86) | 2.04 (1.61, 2.58) | <0.001 |
| Age, adjusted | Reference | 1.35 (1.05, 1.73) | 1.46 (1.14, 1.86) | 2.05 (1.61, 2.60) | <0.001 |
| Multivariate model 1a | Reference | 1.27 (0.98, 1.64) | 1.22 (0.94, 1.57) | 1.64 (1.28, 2.10) | <0.001 |
| Multivariate model 2b | Reference | 1.27 (0.98, 1.64) | 1.22 (0.94, 1.58) | 1.63 (1.26, 2.11) | <0.001 |
| Female | |||||
| Univariate model | Reference | 1.52 (1.24, 1.85) | 2.00 (1.65, 2.43) | 2.47 (2.04, 2.99) | <0.001 |
| Age, adjusted | Reference | 1.52 (1.25, 1.86) | 2.02 (1.67, 2.46) | 2.54 (2.09, 3.08) | <0.001 |
| Multivariate model 1a | Reference | 1.36 (1.10, 1.68) | 1.60 (1.30, 1.97) | 1.78 (1.44, 2.19) | <0.001 |
| Multivariate model 2b | Reference | 1.35 (1.09, 1.67) | 1.59 (1.29, 1.96) | 1.76 (1.42, 2.19) | <0.001 |
| Normal-weight persons | |||||
| Univariate model | Reference | 1.49 (1.17, 1.90) | 1.76 (1.39, 2.24) | 2.20 (1.74, 2.77) | <0.001 |
| Age and gender, adjusted | Reference | 1.49 (1.17, 1.91) | 1.77 (1.39, 2.25) | 2.24 (1.77, 2.83) | <0.001 |
| Multivariate model 1a | Reference | 1.49 (1.17, 1.91) | 1.77 (1.39, 2.24) | 2.24 (1.77, 2.83) | <0.001 |
| Multivariate model 2b | Reference | 1.50 (1.17, 1.93) | 1.80 (1.41, 2.29) | 2.23 (1.75, 2.85) | <0.001 |
| Overweight/obese persons | |||||
| Univariate model | Reference | 1.13 (0.92, 1.38) | 1.17 (0.95, 1.43) | 1.53 (1.26, 1.87) | <0.001 |
| Age and gender, adjusted | Reference | 1.13 (0.92, 1.39) | 1.21 (0.98, 1.48) | 1.63 (1.33, 2.00) | <0.001 |
| Multivariate model 1a | Reference | 1.14 (0.92, 1.40) | 1.20 (0.98, 1.48) | 1.63 (1.32, 2.00) | <0.001 |
| Multivariate model 2b | Reference | 1.10 (0.90, 1.36) | 1.15 (0.93, 1.42) | 1.56 (1.25, 1.93) | <0.001 |
The quartiles of SUA concentration were computed sex, respectively. In male, the cutoff of SUA concentration is <4.47, ≥4.47, ≥5.23, and ≥6.10 mg/dl, respectively, and in female <3.53, ≥3.53, ≥4.15, and ≥4.84 mg/ml, respectively. aAdjusted for the age (continuous), sex (male and female), BMI (continuous) plus smoking (never smoking, quit smoking, and smoking), drinking (never drinking, quit drinking, and drinking), and physical activity (yes/no). In analysis of men and women, adjusted for age (continuous), BMI (continuous), smoking (never smoking, quit smoking, and smoking), drinking (never drinking, quit drinking, and drinking), and physical activity (yes/no). bAdjusted for the same set of variables in model 1 plus prevalence (yes/no) of CHD, hypertension, diabetes, ALT concentration (continuous), Cre concentration (continuous), and FPG concentration (continuous).