Table 4.
Association between SUA and elevated levels of serum ALT, GGT, APRI, or FIB 4 among NAFLD.
| Quartiles of SUA | Elevated ALT (%) | Adjusteda OR of elevatedc ALT | Elevated GGT (%) | Adjusteda OR of elevatedc GGT | Elevated APRI (%) | Adjusteda OR of elevatedc APRI | Elevated FIB 4 (%) | Adjustedb OR of elevatedc FIB 4 |
|---|---|---|---|---|---|---|---|---|
| Q1 | 28.37 | Reference | 10.26 | Reference | 6.04 | Reference | 11.07 | Reference |
| Q2 | 30.10 | 1.08 (0.81, 1.45) | 13.86 | 1.46 (0.99, 2.17) | 7.72 | 1.43 (0.86, 2.37) | 10.89 | 1.04 (0.69, 1.58) |
| Q3 | 31.00 | 1.17 (0.87, 1.57) | 15.80 | 1.74 (1.18, 2.57) | 9.20 | 1.71 (1.05, 2.81) | 13.00 | 1.31 (0.87, 1.95) |
| Q4 | 35.64 | 1.57 (1.17, 2.11) | 20.40 | 2.45 (1.67, 3.59) | 14.65 | 2.92 (1.83, 4.67) | 16.24 | 1.62 (1.09, 2.41) |
| Odds ratio per unit (mg/dl) increase in SUA | ||||||||
| All persons | N/A | 1.14 (1.05, 1.24) | N/A | 1.27 (1.15, 1.40) | N/A | 1.32 (1.18, 1.48) | N/A | 1.17 (1.05, 1.29) |
| Male | N/A | 1.19 (1.03, 1.39) | N/A | 1.26 (1.06, 1.50) | N/A | 1.19 (1.01, 1.40) | N/A | 1.12 (0.98, 1.29) |
| Female | N/A | 1.13 (1.02, 1.25) | N/A | 1.31 (1.15, 1.48) | N/A | 1.47 (1.25, 1.74) | N/A | 1.23 (1.05, 1.44) |
| Normal BMI | N/A | 1.17 (1.02, 1.36) | N/A | 1.33 (1.14, 1.57) | N/A | 1.42 (1.16, 1.73) | N/A | 1.22 (0.98, 1.51) |
| Over BMI | N/A | 1.15 (1.06, 1.25) | N/A | 1.28 (1.15, 1.40) | N/A | 1.33 (1.18, 1.49) | N/A | 1.16 (1.03, 1.30) |
The quartiles of SUA concentration were computed sex, respectively. In male, the cutoff of SUA concentration is <5.26, ≥5.26, ≥6.08, and ≥7.16, respectively, and in female <4.29, ≥4.29, ≥5, and ≥5.78, respectively. Abbreviation: N/A: not applicable. aAdjusted for the age (continuous), sex (male and female), BMI (continuous) plus smoking (never smoking, quit smoking, and smoking), drinking (never drinking, quit drinking, and drinking), physical activity (yes/no), Cre concentration (continuous), FPG concentration (continuous), and prevalence of hypertension, CHD, and diabetes (yes/no). bAdjusted for the same multivariable of model a without age. cAn elevated ALT was a level > 30 U/l for male and >19 U/l for female; an elevated GGT level was a level > 51 U/l for male and >33 U/l for female; an elevated APRI level was >0.5 for both male and female, and elevated FIB-4 level was >2.67 for both male and female.