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. 2022 Mar 15;2022:1792412. doi: 10.1155/2022/1792412

Figure 7.

Figure 7

Downregulated GAS5/Ang-2 or elevated miR-17-3p arrests IL-1β-induced apoptosis and facilitates the proliferation of HDNPCs. (a) The viability of NPCs evaluated by CCK-8 assay. (b) Western blot analysis of Ang-2 protein in NPCs, which was normalized to GAPDH. (c) Western blot analysis of cleaved caspase-3 protein in NPCs, which was normalized to GAPDH. (d) Western blot analysis of cleaved caspase-7 protein in NPCs, which was normalized to GAPDH. (e) Western blot analysis of cleaved caspase-9 protein in NPCs, which was normalized to GAPDH. (f) Statistical results of TUNEL-positive NPCs. ∗p < 0.05 vs. HDNPCs without any treatment; #p < 0.05 vs. HDNPCs treated with si-NC and 10 ng/mL IL-1β; $p < 0.05 vs. HDNPCs treated with NC mimic and 10 ng/mL IL-1β. Data (mean ± standard deviation) were assessed by one-way ANOVA, followed by Tukey's post hoc test, while those in (a) were examined with repeated measures ANOVA, followed by Bonferroni test. The cell experiment was repeated independently 3 times.