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. 2021 Aug 19;161(2):407–417. doi: 10.1016/j.chest.2021.07.2177

Figure 2.

Figure 2

Flow diagram of longitudinal cohort studies. The ALTOS examined patient outcomes 6 and 12 months after enrollment into four National Institutes of Health-funded ARDS Network Clinical Trials for patients with ARDS. Data on health-related outcomes were collected by phone via a battery of validated surveys for survivors from 41 hospitals at 11 study centers across the United States. Participants from five of 11 ARDS Network centers provided additional data on formal education, comorbidities before ARDS, and retrospective perception of their health before ARDS. The ICAP prospective cohort study evaluated the effects of lower tidal volume ventilation and other aspects of critical illness and ICU care on the long-term physical and mental health outcomes of participants at 13 ICUs at four hospitals in Baltimore, Maryland. Follow-up assessments were conducted at 6 and 12 months. ALTOS = ARDSNet Long Term Outcomes Study; ICAP = Improving Care of Acute Lung Injury Patients.