Table 3.

Effect Estimates of Ever-PRISm Status as a Predictor of Significant Transitions in COPDGene

Predictor: Ever-PRISm (phase 1 to phase 3)	OR (95% CI)
Unadjusted	10.3 (7.9-13.5)
Clinical predictors	14.9 (10.9-20.7)
Clinical and radiographic predictors	14.3 (9.9-21)

Clinical predictors included sex, Black race, baseline age, baseline FEV₁ % predicted, current smoking status at baseline, BMI, pack-years, and ever having a positive bronchodilator response. Radiographic predictors included percent emphysema and percent gas trapping at baseline. PRISm = preserved ratio impaired spirometry; Significant transition = change in lung function category plus > 10% change in FEV₁ % predicted or FVC % predicted between consecutive study visits (phase 1 to phase 2 or phase 2 to phase 3).