Table 3. Structural Group 3: Summary of Carcinogenic Potencies for Group AI Determination^26,31,32,h.

^aAs reported in LCDB unless otherwise noted; the TD₅₀ from the most sensitive organ site from the study deemed most robust is reported.

^bThe AI for structural group 3 was calculated based on the worst-case TD₅₀ from N-nitroso-N-methylaniline.

^cGold TD₅₀ reported in LCDB, but results are not statistically significant.

^dWhen a user enters CAS number 21928-82-5 into LCDB, it will pull back a record associated with N⁶-methyladenosine. It should be noted that the CAS number provided in CPDB and LCDB corresponds to the structure for N⁶-(methylnitroso)adenine in CAS (though CAS does list both names). There is no unique CAS number provided for N⁶-(methylnitroso)adenosine. The data presented in LCDB do correspond to that for N⁶-(methylnitroso)adenosine from Anderson et al.³¹

^eWhen a user enters CAS number 21928-82-5 into LCDB, it will pull back a record of carcinogenicity data associated with N⁶-methyladenosine. However, this CAS number is associated with N⁶-(methylnitroso)adenine in CAS and one must refer to the source document³¹ to find the relevant carcinogenicity data for N⁶-(methylnitroso)adenine.

^fTD₅₀ calculated.

^gNo data reported in the LCDB or the CPDB.

^hLCDB, Lhasa Carcinogenicity Database; TD₅₀, dose producing a 50% tumor incidence.