Table 5. Structural Group 5: Summary of Carcinogenic Potencies for Group AI Determination^26,35−37,f.

^aAs reported in LCDB unless otherwise noted; the TD₅₀ from the most sensitive organ site from the study deemed the most robust study is reported.

^bThe AI for structural group 5 considered the worst-case TD₅₀ from 3-hydroxy-N-nitrosopiperidine as well as the associated TD₅₀ 95% lower confidence interval.

^cCI in parentheses.

^dTD₅₀, as well as upper and lower 95% confidence intervals, was calculated.

^eStudy design does not allow for a reliable estimate of TD₅₀. Dosing was limited to 3× per week for 7.3 weeks

^fLCDB, Lhasa Carcinogenicity Database; TD₅₀, dose producing a 50% tumor incidence; ND, not determined.