Wijnen 2002.

Methods	Study design: Parallel RCT
Participants	Inclusion criteria Setting: single centre Country: Netherlands Patients needing elective surgery for an infrarenal abdominal aneurysm Number: treatment group (20); control group (22) Mean age; range: treatment group (67; 51‐75); control group (70; 59‐82) Exclusion criteria Patients with kidney failure; high‐risk patients due to cardiac or pulmonary illness
Interventions	Treatment group Standard therapy Antioxidant therapy: 200 mg vitamin E, 5 days prior to the operation; 2000 mg vitamin C, on the morning of the operation; 300 mg allopurinol, 1 day before surgery; 300 mg N‐acetylcysteine (150 mg/kg before the start of the operation and 200 mg/kg in a drip over 12 hours); 10% 500 mg/mL mannitol in 12 hours starting at the beginning of surgery Control group Standard therapy only
Outcomes	Renal function defined as urine albumin:creatinine ratio, CrCl SCr Mean change in GFR
Notes	Follow‐up: 7 days
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	No information provided regarding randomisation procedures
Allocation concealment (selection bias)	Unclear risk	No information provided regarding allocation concealment
Blinding (performance bias and detection bias) All outcomes	Unclear risk	No information provided regarding blinding
Incomplete outcome data (attrition bias) All outcomes	Low risk	The study reported outcomes for all patients initially randomised patients
Selective reporting (reporting bias)	Unclear risk	The methods section of the study reported what was performed; however, there were pre‐specified outcomes
Other bias	Unclear risk	Funding: not stated

AKI ‐ acute kidney injury; CKD ‐ chronic kidney disease; CrCl ‐ creatinine clearance; eGFR ‐ estimated glomerular filtration rate; GFR ‐ glomerular filtration rate; RCT ‐ randomised controlled trial; SCr ‐ serum creatinine