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Apoptosis signaling pathways. Overview of the intrinsic (mitochondrial), extrinsic or death receptor (DR), and ER-stress (ERS)-mediated apoptosis pathways in response to the molecular action of anticancer agents as well as the TRADD/NF-κB survival pathway, the growth factor (GF) receptors, and PI3K/Akt pro-survival signaling axis in CSCs
