TABLE 2.

Quantification by RNAseq of differential expression of validated mRNA targets of differentially expressed miRNAs^a

mRNA	FC	FDR	DESCRIPTION
IRS1	2.77	0.0003	Insulin Receptor Substrate 1
GZMB	−6.27	0.000	Granzyme B
MEF2C	2.58	0.001	Myocyte Enhancer Factor 2C

^aLung expression levels, quantified by RNA-seq, of validated mRNA targets (Fig. 1C) of miRNAs 223-3p, 145a-5p, 33-5p, 107-3p, and 320-3p, differentially expressed in the lungs of mice infected with SARS-CoV-ΔE or SARS-CoV-WT at 2 days p.i. Only mRNAs with FC > 2 or < −2 and FDR < 0.05 are shown.