FIG 2.

Chemical and antibacterial characteristics on H. pylori of the primary screen hit Active1 (β-lapachone) which had direct specific antibacterial effects against H. pylori. panel A) depicts the chemical structure of Active1 (β-lapachone), which inhibited both flagellar reporter activity and bacterial growth and vitality. In panel B) IC₅₀ determination of the flaA-luciferase reporter activity for this compound (primary screen), in C) IC₅₀ determination for the metabolic activity (counterscreen and assay) and in D) MIC/MBC values for the same compound, which exhibits very strong antibacterial activity against H. pylori, are given.