FIG 10.

Working model of PPxY-WW domain interactions among AMOT, WWOX, and VP40. (Left) AMOTp130 facilitates VP40 VLP egress via its ability to bind actin and regulate its dynamics at the plasma membrane. (Right) Exogenously expressed WWOX interacts with both AMOTp130 and VP40 in a PPxY-WW domain-dependent manner. These interactions lead to reduced levels of VP40 at the plasma membrane, enhanced nuclear localization of VP40 (red arrow), and lysosomal-mediated degradation of AMOTp130 (black arrow), all of which results in a decrease of VLP egress.