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. Author manuscript; available in PMC: 2022 Mar 23.
Published in final edited form as: Cell. 2021 Dec 14;184(26):6262–6280.e26. doi: 10.1016/j.cell.2021.11.031

Figure 3. Inferred origins of pre-cancers.

Figure 3.

(A–D) Multiplex images of colonic polyps and normal tissues for (A) SOX9, (B) OLFM4, (C) CDX2, and (D) MUC5AC. (Right) Image quantification (n = 20 polyps per subtype).

(E) p-Creode analysis on epithelial regulon landscapes, for (top) DIS and (bottom) VAL datasets. For gene overlays, node size represents cell proportion and intensity represents scaled expression.

(F) RNA velocity for representative NL, TA, and SSL overlaid on combined UMAP embedding for DIS. Vectors inferring average transitions shown as black arrows. Colored points are cells derived from the representative specimen, and gray points are all other cells in the dataset.

*p < 0.05, **p < 0.01, ****p < 0.0001. See also Figure S3.