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. Author manuscript; available in PMC: 2022 Mar 23.
Published in final edited form as: Cell. 2021 Dec 14;184(26):6262–6280.e26. doi: 10.1016/j.cell.2021.11.031

Figure 5. Heterogeneity of CRCs with metaplastic and stem-like features.

Figure 5.

(A) IHC scans for MUC5AC and CDX2 of CRCs.

(B) Image quantification of n = 17 MSS and n = 14 MSI-H CRCs.

(C and D) (C) Low-mag. view and (D) high-mag. view of a MSS CRC with protein markers.

(E) Low-mag. view of a MSI-H CRC.

(F) High-mag. view of MUC5AC high and low areas for metaplasia markers of the CRC in (E).

(G and H) Same as in (E) and (F) but for stem cell markers. Black rectangles in the restitched image represent fields of views that were not scanned.

(I) UMAP of scRNA-seq data of the MSI-H CRC in (E) overlaid with markers and cell cycle signatures.

*p < 0.05, **p < 0.01.