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. Author manuscript; available in PMC: 2022 Mar 23.
Published in final edited form as: Cell Rep. 2022 Mar 1;38(9):110442. doi: 10.1016/j.celrep.2022.110442

Figure 1. Sex-stratified global and regional DNA methylation profiles of placenta and fetal brain from mice with prenatal PCB exposure.

Figure 1.

(A–D) Density plots of smoothed single CpG methylation values from (A) female placenta, (B) male placenta, (C) female brain, and (D) male brain.

(E–H) Heatmaps of hierarchal clustering of the Z scores of regional smoothed methylation values for DMRs identified from pairwise comparisons of (E) female placenta, (F) male placenta, (G) female brain, and (H) male brain.

A total of 44 placenta and 44 fetal brain methylomes were generated from PCB-exposed GD18 males (n = 11) and females (n = 12) and matched vehicle control males (n = 10) and females (n = 11).