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. Author manuscript; available in PMC: 2022 Mar 23.
Published in final edited form as: Cell Rep. 2022 Mar 1;38(9):110442. doi: 10.1016/j.celrep.2022.110442

Figure 4. Overlaps between PCB exposure DMRs from placenta and fetal brain.

Figure 4.

(A) Permutation analysis of the genomic coordinate enrichment of the sex-combined consensus fetal brain DMRs within the sex-combined consensus placenta DMRs.

(B) UpSet plot of the gene symbol mapping overlaps for all pairwise DMR comparisons.

(C) Top significant (q < 0.05) slimmed GO terms, PANTHER pathways, and GEO RNA-seq dataset enrichments from a meta p value analysis of gene symbol mappings from the sex-stratified overlaps of placenta and fetal brain. The GEO RNA-seq dataset enrichments are stratified by whether the genes were up- or down-regulated.

(D) Heatmap of unique DMR gene symbol mappings that are shared between the female and male placenta-brain overlaps and repressed by MeCP2 in the hypothalamus of mouse models of Rett syndrome.