Table 1.

Top 10 DMRs from sex-stratified pairwise comparisons of prenatal PCB-exposed placenta and fetal brain

Chr	Region	Symbol	Name	Change	p value
Placenta: female
9	intron	5830454E08Rik	RIKEN cDNA 5830454E08 gene	13%	9.0e-06
12	intron	Ifrd1	Interferon-related developmental regulator 1	14%	9.0e–06
X	promoter	Msl3	MSL complex subunit 3	−10%	1.0e–05
11	promoter	Cpsf4l	Cleavage and polyadenylation specific factor 4-like	12%	1.2e–05
7	exon	Ryr1	Ryanodine receptor 1, skeletal muscle	−9%	1.3e–05
2	intergenic	Kcnj3	Potassium inwardly rectifying channel, subfamily J, member 3	16%	3.3e–05
2	exon	Jph2	Junctophilin 2	−9%	3.3e–05
6	exon	Zfp282	Zinc finger protein 282	−12%	3.8e–05
5	exon	Ints1	Integrator complex subunit 1	13%	5.0e–05
18	intergenic	Rit2	Ras-like without CAAX 2	−25%	6.2e–05
Placenta: male
11	exon	Shroom1	Shroom family member 1	21%	4.0e–06
5	intron	Wasf3	WAS protein family, member 3	−18%	6.0e–06
15	3′ UTR	Cdh18	Cadherin 18	−16%	1.0e–05
6	promoter	Clstn3	Calsyntenin 3	−15%	1.1e–05
2	intergenic	Fsip2	Fibrous sheath-interacting protein 2	−17%	1.1e–05
11	intergenic	1700092K14Rik	RIKEN cDNA 1700092K14 gene	−11%	1.5e–05
16	intron	Erg	ETS transcription factor	−10%	1.6e–05
17	intergenic	4930470H14Rik	RIKEN cDNA 4930470H14 gene	−14%	1.6e–05
4	intergenic	Elavl2	ELAVlike RNA binding protein 1	−17%	1.9e–05
10	intron	Lama2	Laminin, alpha 2	−14%	1.9e–05
Brain: female
9	intergenic	2900052N01Rik	RIKEN cDNA 2900052N01 gene	−13%	2.9e–05
16	intron	Mir99ahg	Mir99a and Mirlet7c-1 host gene	−12%	4.7e–05
12	intergenic	Begain	Brain-enriched guanylate kinase-associated	−12%	9.4e–05
5	intron	Vps37b	Vacuolar protein sorting 37B	11%	1.4e–04
X	intergenic	Bcor	BCL6 interacting corepressor	−8%	1.4e–04
14	exon	Gm30214	Predicted gene, 30214	38%	2.0e–04
12	exon	Elmsan 1	ELM2 and Myb/SANT-like domain containing 1	−20%	2.2e–04
14	exon	2900040C04Rik	RIKEN cDNA 2900040C04 gene	−15%	2.6e–04
14	intron	Wdfy2	WD repeat and FYVE domain containing 2	−11%	2.7e–04
2	intron	Myo3b	Myosin IIIB	−11%	2.9e–04
Brain: male
5	intergenic	Castor2	Cytosolic arginine sensor for mTORC1 subunit 2	−29%	2.7e–06
8	intron	Tenm3	Teneurin transmembrane protein 3	15%	8.0e–06
11	3′ UTR	Camk2b	Calcium/calmodulin-dependent protein kinase II, beta	−9%	1.9e–05
13	intron	Wnk2	WNK lysine deficient protein kinase 2	13%	1.9e–05
3	promoter	Dapp1	Dual adaptor for phosphotyrosine and 3-phosphoinositides 1	9%	3.2e–05
3	intron	Lrba	LPS-responsive beige-like anchor	−10%	6.7e–05
X	promoter	Mid1	Midline 1	−13%	8.0e–05
8	intergenic	Maf	Avian musculoaponeurotic fibrosarcoma oncogene homolog	−13%	9.1e–05
14	intron	Extl3	Exostosin-like glycosyltransferase 3	12%	1.0e–04
2	intron	Cd44	CD44 antigen	−12%	1.3e–04