Table II.
Correlation between E-cadherin expression and clinic-pathological parameters
| Parameter | Total (N = 100) | E cadherin expression – carcinoma intensity | χ2 | P-value | ||||
|---|---|---|---|---|---|---|---|---|
| 0 | 1+ | 2+ | 3+ | |||||
| Age [years]: | ||||||||
| < 45 | 26 | 4 (15.4) | 10 (38.5) | 8 (30.8) | 4 (15.4) | 4.620 | 0.202 | |
| > 45 | 74 | 6 (8.1) | 17 (23.0) | 29 (39.2) | 22 (29.7) | |||
| Sex: | ||||||||
| Male | 58 | 9 (15.5) | 15 (25.9) | 20 (34.5) | 14 (24.1) | 4.690 | 0.196 | |
| Female | 42 | 1 (2.4) | 12 (28.6) | 17 (40.5) | 12 (28.6) | |||
| Size of tumor [cm]: | ||||||||
| < 5 | 37 | 5 (13.5) | 12 (32.4) | 11 (29.7) | 9 (24.3) | 3.393 | 0.758 | |
| 5–9.99 | 55 | 4 (7.3) | 13 (23.6) | 22 (40.0) | 16 (29.1) | |||
| > 10 | 8 | 1 (12.5) | 2 (25.0) | 4 (50.0) | 1 (12.5) | |||
| Sites: | ||||||||
| Rectum | 38 | 2 (5.3) | 10 (26.3) | 19 (50.0) | 7 (18.4) | 5.539 | 0.136 | |
| Colon | 62 | 8 (12.9) | 17 (27.4) | 18 (29.3) | 19 (30.6) | |||
| Tumour invasion (T status): | ||||||||
| PT1 | 1 | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (100.0) | 6.793 | 0.659 | |
| PT2 | 42 | 2 (4.8) | 10 (23.8) | 19 (45.2) | 11 (26.2) | |||
| PT3 | 42 | 6 (14.3) | 12 (28.6) | 14 (33.3) | 10 (23.8) | |||
| PT4 | 15 | 2 (13.3) | 5 (33.3) | 4 (26.7) | 4 (26.7) | |||
| Lymph node involvement (N status): | ||||||||
| NX | 6 | 1 (16.7) | 0 (0.0) | 4 (66.7) | 1 (16.7) | 22.82 | 0.007 | |
| N0 | 54 | 7 (13.0) | 12 (22.2) | 20 (37.0) | 15 (27.8) | |||
| N1 | 27 | 0 (0.0) | 6 (22.2) | 13 (48.1) | 8 (29.6) | |||
| N2 | 13 | 2 (15.4) | 9 (69.2) | 0 (0.0) | 2 (15.4) | |||
| Metastasis: | ||||||||
| M0 | 95 | 26 (27.4) | 36 (37.9) | 24 (25.3) | 9 (9.5) | 4.196 | 0.650 | |
| M1 | 2 | 0 (0.0) | 1 (50.0) | 1 (50.0) | 0 (0.0) | |||
| MX | 3 | 1 (33.3) | 0 (0.0) | 1 (33.3) | 1 (33.3) | |||
| Tumour differentiation pattern: | ||||||||
| Poorly differentiated | 13 | 5 (38.5) | 4 (30.8) | 2 (15.4) | 2 (15.4) | 17.131 | 0.009 | |
| Moderately differentiated | 74 | 3 (4.1) | 19 (25.7) | 30 (40.5) | 22 (29.7) | |||
| Well differentiated | 13 | 2 (15.4) | 4 (30.8) | 5 (38.5) | 2 (15.4) | |||
| Cytoplasm or membrane: | ||||||||
| Negative/NA | 10 | 10 | 0 (0.0) | 0 (0.0) | 0 (0.0) | 104.32 | < 0.001 | |
| Membrane | 10 | 0 (0.0) | 4 (40.0) | 3 (30.0) | 3 (30.0) | |||
| Cytoplasm | 37 | 0 (0.0) | 14 (37.8) | 15 (40.5) | 8 (21.6) | |||
| Membrane and cytoplasm | 43 | 0 (0.0) | 9 (20.9) | 19 (44.2) | 15 (34.9) | |||