Table 1.

The classification of virulence related factors of S. algae species against VFDB

Cluster	VF-class	Virulence factor	Functions of productions
C1	Acid resistance	Urease	Protein biosynthesis
C1	Adherence	Accessory colonization factor, Mannose-sensitive hemagglutinin4, Type IV pilus, Flagella4, Flp type IV pili, LPS O-antigen, Tap type IV pili, tad locus	Flagellum assembly, pilus assembly, protein secretion, signals transduction, translocation, hydrolase
C1	Anaerobic respiration	Nitrate reductase	Catalytic activity
C1	Antiphagocytosis	Capsular polysaccharide	LPS biosynthesis and metabolism, catalytic activity
C1	Biofilm formation	AdeFGH efflux pump/transport autoinducer	Catalytic activity
C1	Chemotaxis and motility	Flagella	Flagellum biogenesis, motor activity, pathogenesis
C1	Efflux pump	AcrAB, MtrCDE	Efflux
C1	Toxin	Hemolysin III, Phytotoxin phaseolotoxin, Endotoxin	Signalling receptor, protein kinase activity
C1	Immune evasion	Capsule, LPS, Exopolysaccharide	Metabolism, stationary phase survival, catalytic activity, biosynthesis
C1	Nutritional virulence	Biotin metabolism, Cysteine acquisition, Pyrimidine biosynthesis	Biotin metabolism, chemotaxis signal transduction, signals transmission
C2	Adherence	Accessory colonization factor, Mannose-sensitive hemagglutinin4, Type IV pilus, Flagella4, Flp type IV pili, LPS O-antigen, Tap type IV pili, tad locus	Flagellum assembly, pilus assembly, protein secretion, signals transduction, translocation, hydrolase
C2	Chemotaxis and motility	Flagella	Flagellum biogenesis, motor activity, pathogenesis
C2	Secretion system	EPS type II secretion system, VAS type VI secretion system3, T4SS effectors	Protein secretion and transport, virulence, chaperone
C2	Glycosylation system	O linked flagellar glycosylation	Catalytic activity
C3	Adherence	Accessory colonization factor, Mannose-sensitive hemagglutinin4, Type IV pilus, Flagella4, Flp type IV pili, LPS O-antigen, Tap type IV pili, tad locus	Flagellum assembly, pilus assembly, protein secretion, signals transduction, translocation, hydrolase
C3	Antiphagocytosis	Capsular polysaccharide	LPS biosynthesis and metabolism, catalytic activity
C3	Chemotaxis and motility	Flagella	Flagellum biogenesis, motor activity, pathogenesis
C3	Immune evasion	Capsule, LPS, Exopolysaccharide	Metabolism, stationary phase survival, catalytic activity, biosynthesis
C3	Iron uptake	Enterobactin receptors, Periplasmic binding protein-dependent ABC transport systems, Cytochrome c maturation locus, Haemophilus iron transport locus, biosynthesis	Transcription activation, signalling receptor, transport, catalase activity
C3	Endotoxin	Lipooligosaccharide (LOS) (Haemophilus)	Catalytic activity
C3	Protease	Zn2+ metallophrotease	Endoprotease
C3	Stress adaptation	Catalase, SodCI	Catalytic activity, destroys radicals
C4	Adherence	Accessory colonization factor, Mannose-sensitive hemagglutinin4, Type IV pilus, Flagella4, Flp type IV pili, LPS O-antigen, Tap type IV pili, tad locus	Flagellum assembly, pilus assembly, protein secretion, signals transduction, translocation, hydrolase
C4	Chemotaxis and motility	Flagella	Flagellum biogenesis, motor activity, pathogenesis
C4	Endotoxin	LOS (Haemophilus)	Endotoxin
C4	Immune evasion	Capsule, LPS, Exopolysaccharide	Metabolism, stationary phase survival, catalytic activity, biosynthesis
C4	Phagosome arresting	Nucleoside diphosphate kinase	Nucleoside triphosphates synthesis
C4	Quorum sensing	Autoinducer-2, PhoPQ, Two component system	Autoinducer synthesis, regulation of transcription
C4	Regulation	Two component system	Signal transduction
C4	Stress adaptation	Catalase, SodCI	Catalytic activity, destroys radicals
C4	Toxin	Hemolysin III, Phytotoxin phaseolotoxin, Endotoxin	Signalling receptor, protein kinase activity
C4	Secretion system	EPS type II secretion system, VAS type VI secretion system3, T4SS effectors	Protein secretion and transport, virulence, chaperone
C5	Iron uptake	Enterobactin receptors, Periplasmic binding protein-dependent ABC transport systems, Cytochrome c maturation locus, Haemophilus iron transport locus, biosynthesis	Transcription activation, signalling receptor, transport, catalase activity
C5	Adherence	Accessory colonization factor, Mannose-sensitive hemagglutinin4, Type IV pilus, Flagella4, Flp type IV pili, LPS O-antigen, Tap type IV pili, tad locus	Flagellum assembly, pilus assembly, protein secretion, signals transduction, translocation, hydrolase
C5	Antiphagocytosis	Capsular polysaccharide	LPS biosynthesis and metabolism, catalytic activity