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(a) FrpB-4 (MWE_1700) modelled on PDB 4AIQ (FrpB of N. meningitidis). The left figure shows East Asia-specific sites. NE means north east China. The right one shows Americas-specific sites. (b) TonB-dependent transport system. When the transporter in the outer membrane catches a ligand, it pushes out its plug for TonB to pull and open the channel. This movement of TonB is energized by ExbBD motor in the inner membrane driven by H+ flow.
