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. Author manuscript; available in PMC: 2022 Nov 1.
Published in final edited form as: Phytother Res. 2021 Oct 26;35(11):6255–6269. doi: 10.1002/ptr.7271

FIGURE 7.

FIGURE 7

Cyanidin treatments improved bone recovery after heat-shock induction of resorption in Col10α1:mGFP/Rankl:HSE: CFP Medaka larvae. (a) Fixed bone staining with Alizarin Red in Col10α1:mGFP/Rankl:HSE:CFP medaka larvae at 14 dpf. (b) Fixed bone staining with Alizarin Red in Col10α1:mGFP/Rankl:HSE:CFP larvae at 14 dpf after RANKL red after RANKL induction. (c,d) Fixed bone staining with Alizarin Red in Col10α1:mGFP/Rankl:HSE:CFP larvae at 14 dpf after RANKL induction and treatment with 0.5 and 2.0 μg/ml Cyanidin. 0.5 μg/ml was not effective in reducing heat-shock-induced bone resorption; however, treatment of the medaka with 2.0 μg/ml of cyanidin reduced mineralized bone matrix degradation by RANKL-induced ectopic osteoclasts by an average of 21%