Comparison 1. Traditional NSAID vs Placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Pain on VAS	4	850	Mean Difference (IV, Random, 95% CI)	‐16.51 [‐20.84, ‐12.17]
2 Withdrawals due to adverse events	5	1165	Risk Ratio (M‐H, Random, 95% CI)	0.75 [0.46, 1.21]
3 BASDAI	1		Mean Difference (IV, Random, 95% CI)	Totals not selected
4 Patient's global assessment of disease activity	3	705	Mean Difference (IV, Random, 95% CI)	‐17.75 [‐24.39, ‐11.10]
5 Duration of morning stiffness	4	850	Std. Mean Difference (IV, Random, 95% CI)	‐0.40 [‐0.58, ‐0.22]
6 CRP	2	515	Mean Difference (IV, Random, 95% CI)	‐3.37 [‐6.11, ‐0.62]
7 ASAS 20	2	503	Risk Ratio (M‐H, Random, 95% CI)	2.49 [1.94, 3.18]
8 ASAS partial remission	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
9 BASFI	2	356	Mean Difference (IV, Random, 95% CI)	‐9.07 [‐13.04, ‐5.10]
10 Chest expansion	2	515	Mean Difference (IV, Random, 95% CI)	0.44 [0.20, 0.68]
11 Schober's test	4	850	Mean Difference (IV, Random, 95% CI)	0.37 [0.18, 0.57]
12 Pain relief ≥ 50%	3	660	Risk Ratio (M‐H, Random, 95% CI)	2.27 [1.77, 2.91]
13 Number of any adverse events	5	1289	Risk Ratio (M‐H, Random, 95% CI)	1.08 [0.92, 1.26]
14 Number of serious adverse events	3	671	Risk Ratio (M‐H, Random, 95% CI)	1.69 [0.36, 7.97]
15 Number of adverse events per organ system	5		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
15.1 Gastro‐intestinal	5	1289	Risk Ratio (M‐H, Random, 95% CI)	1.92 [1.41, 2.61]
15.2 Respiratory	4	1145	Risk Ratio (M‐H, Random, 95% CI)	0.91 [0.54, 1.51]
15.3 Hematological	1	166	Risk Ratio (M‐H, Random, 95% CI)	2.54 [0.10, 61.42]
15.4 Neurological	4	1144	Risk Ratio (M‐H, Random, 95% CI)	0.44 [0.24, 0.82]
15.5 Dermatological	3	952	Risk Ratio (M‐H, Random, 95% CI)	0.86 [0.27, 2.67]