Comparison 3. COX‐2 vs traditional NSAID.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Pain on VAS	3	669	Mean Difference (IV, Random, 95% CI)	‐2.62 [‐10.99, 5.75]
2 Withdrawals due to adverse events	4	995	Risk Ratio (M‐H, Random, 95% CI)	1.04 [0.60, 1.82]
3 BASDAI	2	499	Mean Difference (IV, Random, 95% CI)	‐0.75 [‐7.95, 6.45]
4 Patient's global assessment of disease activity	3	669	Mean Difference (IV, Random, 95% CI)	‐3.09 [‐12.24, 6.07]
5 Duration of morning stiffness	2	367	Std. Mean Difference (IV, Random, 95% CI)	‐0.95 [‐2.81, 0.90]
6 CRP	2	472	Mean Difference (IV, Random, 95% CI)	‐0.92 [‐2.90, 1.07]
7 ASAS 20	3	663	Risk Ratio (M‐H, Random, 95% CI)	1.00 [0.80, 1.25]
8 ASAS partial remission	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
9 BASFI	3	669	Mean Difference (IV, Random, 95% CI)	‐2.12 [‐6.53, 2.29]
10 BASMI	1		Mean Difference (IV, Random, 95% CI)	Totals not selected
11 Chest expansion	1		Mean Difference (IV, Random, 95% CI)	Totals not selected
12 Schober's test	2	367	Mean Difference (IV, Random, 95% CI)	‐0.14 [‐0.34, 0.07]
13 Pain relief ≥ 50%	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
14 Number of any adverse events	4	995	Risk Ratio (M‐H, Random, 95% CI)	1.01 [0.83, 1.21]
15 Number of serious adverse events	4	995	Risk Ratio (M‐H, Random, 95% CI)	0.72 [0.20, 2.63]
16 Number of adverse events per organ system	4		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
16.1 Cardiovascular	1	305	Risk Ratio (M‐H, Random, 95% CI)	0.15 [0.01, 2.83]
16.2 Gastro‐intestinal	4	995	Risk Ratio (M‐H, Random, 95% CI)	0.90 [0.57, 1.42]
16.3 Hepatic	1	305	Risk Ratio (M‐H, Random, 95% CI)	0.08 [0.00, 1.40]
16.4 Respiratory	4	995	Risk Ratio (M‐H, Random, 95% CI)	0.90 [0.55, 1.46]
16.5 Hematological	1	170	Risk Ratio (M‐H, Random, 95% CI)	0.37 [0.02, 9.06]
16.6 Neurological	4	995	Risk Ratio (M‐H, Random, 95% CI)	1.95 [0.60, 6.35]
16.7 Dermatological	2	488	Risk Ratio (M‐H, Random, 95% CI)	3.80 [0.31, 46.29]