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Permeability coefficients for β-lactams
| Antibiotic | Permeability coefficient (10−5 cm/s)a | Relative permeabilityb |
|---|---|---|
| Ceftazidime | 0.33 ± 0.11 | 0.12 |
| Cefpirome | 0.70 ± 0.14 | 0.26 |
| Meropenem | 2.97 ± 0.32 | 1.1 |
| Imipenem | 17.49 ± 2.00 | 6.4 |
| Piperacillin | 2.72 ± 0.46 | 1.0 |
E. coli MC4100/pHS313 was used in permeability studies.
Values are expressed relative to the permeability coefficient for piperacillin, which was set at 1.0.
