Scheme 1. Total synthesis of the natural chromone 6. Reagents and conditions: (a) MOMCl, DIPEA, DCM, 0 °C to room temperature (rt); (b) prenyl bromide, K2CO3, acetone, reflux; (c) N,N-diethylaniline, microwave; (d) 2N HCl, DCM, MeOH; (e) m-CPBA, M-K10, DCM; (f) DMF-DMA, reflux; (g) I2, MeOH, rt; (h) 4-methoxyphenylboronic acid, Pd(OAc)2, K2CO3, PEG-400; and (i) 3N HCl, DCM, MeOH, reflux.
