Fig. 1.

Correlation between samples and variant burden. a Jaccard similarity coefficients (Jaccard Index) were based on variant allele frequencies (vaf) of all J3, J7, and J14 samples sequenced. Germline variants, variants with vaf < 0.05, and non-protein altering variants were removed for this analysis. b Venn diagrams display the number (and %) of unique and shared variants (SNVs and indels) between cell lines for J3T1 and J3T4, J7T1 and J7T3, and J14T3 and J14T6. Non-synonymous, protein-altering mutations with vaf > 0.05 were included in the analysis