TABLE 3.
Genetic polymorphisms of the kasA gene in INH-resistant and -susceptible clinical isolates of M. tuberculosis
| Phenotype (n) | Codon | Amino acid change | Mutation | No. (%) of isolates with indicated mutation |
|---|---|---|---|---|
| INH resistant (160) | 121a | Arg→Lys | AGG→AAG | 1 (0.6) |
| 269 | Gly→Ser | GGT→AGT | 3 (2) | |
| 312b | Gly→Ser | GGC→AGC | 11 (7) | |
| 387a | Gly→Asp | GGC→GAC | 1 (0.6) | |
| None | None | 144 (90) | ||
| INH susceptible (32) | 312 | Gly→Ser | GGC→AGC | 6 (19) |
| None | None | 26 (81) |
a
Novel mutation.
b
Polymorphism also present in susceptible isolates.