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. 2022 Mar 19;15:3167–3182. doi: 10.2147/IJGM.S353610

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© 2022 Zhang et al.

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Enrichment analyses of SIRT7-related genes. (A) SIRT7-interacting proteins were identified with the STRING database based upon available experimental evidence. (B) The top 100 SIRT7-associated genes in the TCGA dataset were identified using a GEPIA2.0 approach, revealing correlations between SIRT7 and the expression of chosen target genes including ENTHD2, HDAC10, SRRT, NUP85, ARHGEF1, and ANKRD13D. (C) GO and KEGG pathway enrichment analyses were conducted for predicted SIRT7-binding and interacted genes identified in this study.