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. 2022 Mar 19;15:3167–3182. doi: 10.2147/IJGM.S353610

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© 2022 Zhang et al.

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The association between SIRT7 expression and immune cell infiltration in KIRC tumors. (A) Forest plots were used to explore the relationship between SIRT7 expression and infiltration by 24 different immune cell types, with dot size being indicative of absolute Spearman r values. (B–G) Differences in the infiltration of SIRT7-high and -low KIRC tumors by gd T (B), Mast cells (C), iDCs (D), macrophages (E), Neutrophils (F), and Th2 cells (G) were assessed via a WRST approach and through Spearman correlation analyses. (H) Levels of infiltration by varying immune cell types associated with different SIRT7 copy numbers in KIRC. (I) SIRT7 expression differed significantly among different immune subtypes of KIRC, **P < 0.01, ***P < 0.001.