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The biological characteristics and functions of circRNAs. (A) Intron pairing-derived cyclization. (B) Lasso-derived cyclization. (C) RNA binding proteins regulate circRNAs formation. (D) circRNAs adsorption of miRNA as a molecular sponge, playing the role of ceRNA. (E) circRNAs direct binding to mRNA. (F) circRNAs binding to proteins. (G) circRNAs binding to transcription factors. (H) circRNAs encoding small peptides.
