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. 2021 Apr 27;18(2):240–253. doi: 10.1080/15548627.2021.1917131

Figure 3.

Figure 3.

circRNAs affect tumor development and drug resistance by regulating autophagy. In tumor cells, circDNMT1, circCDYL, circ0006528, circABCB10, circMUC16, circMTO1, hsa_circ_0023404, circRACGAP1, circIARS, circPVT1, hsa_circ_0085131, circEIF6, hsa_circ_0035483, circ0009910, circPAN3, and circCCNB2 promote autophagy by promoting the functions of key proteins involved in the autophagy process, whereas circHIPK3, circNRIP1, circ0032821, circKHDC4, circCUL2, circMCTP2, CDR1-AS, circ104075, circ0027345, has_circ_0000515, circ0000285, circCRIM1, and circKMT2D inhibit autophagy by inhibiting the functions of key proteins in the autophagy process. Eventually circRNAs lead to the enhancement of tumor cell invasion, metastasis, proliferation, and drug resistance in patients.