Figure 2.

The second meiotic arrest in metaphase II (MII) oocytes. Loss of the gap junctions (GJs) on the oolemma due to luteinizing hormone (LH) surge prevents entrance of cyclic adenosine monophosphate (cAMP) into ooplasm. Meanwhile, intracellular cAMP is converted to AMP by the enzyme phosphodiesterase (PDE). The phosphatase cell division cycle 25B (CDC25B) dephosphorylates cyclin dependent kinase 1 (CDK1). Thus, maturation promoting factor (MPF) consisting of CDK1 and Cyclin B1 (CCNB1) passes through the nuclear region. GPR, G protein-coupled receptor; Gs, G proteins; CSF, Cytostatic factor; MYT1, Myelin transcription factor 1; cGMP, Cyclic guanosine monophosphate; PB, First polar body. The metaphase plate is depicted at the upper site. The green and red arrows represent activation and repression, respectively.

The oocyte in this figure should also be in a round format as in the word document i have sent in the last e-mail. Please, provide the oocyte in a round format, not in an eliptic format.