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. 2022 Jan 24;21(6):547–571. doi: 10.1080/15384101.2022.2026704

Table 1.

The potential factors leading to permanent meiotic arrests in mammalian germinal vesicle (GV) and metaphase II (MII) oocytes. ND, Not detected. The full names of all abbreviations were given in the text

Arrest stage Lack of gene Gene mutation Down-regulation Up-regulation Inhibition ART application Chemical Other factors
GV oocyte

  • Cdc25b

  • Pde3a

  • Ubb

  • Marf1

  • Ccnb1/Ccnb2

  • PATL2

  • Ccno

  • Plk4

  • Chk2

  • Orf1p

  • Gdf9

  • Bmp15

 ND

  • PDE3

  • CDK1

  • PLK1

  • Transcription

  • Protein synthesis

  • Hyaluronan synthesis

  • Mineral oil

  • FSH/LH

  • Ovarian stimulation

  • Caffeine

  • Metformin

  • Thiamethoxam

  • Absence of Ca+2 channels

  • DSBs

  • Amino acid level
MI oocyte

  • Mlh1

  • Mlh3

  • Cks2

  • Mei1

  • Fmn2

  • Ccnb3

  • PATL2

  • TRIP13

  • TUBB8

  • H1foo

  • Spindly

  • Erk3

  • Syt1

  • Cep55

  • Ccnb3

  • Rasd1

  • Stau2

  • Chk1

  • Prkar2b

  • Survivin

  • Pkcβ1

  • Fbxo30

  • Mat2b

  • Ccnb1

  • Obox4

  • BubR1

  • Chk1

  • Orf1p

  • Mad2

  • MPF

  • Spc25

  • Survivin

  • SPIN1

  • p38 MAPK

  • CHK2

  • EZH2

  • PLD2

  • PAFAH1B3

  • Ovarian stimulation

  • Bisphenol A

  • Thiamethoxam

  • Doxorubicin

  • Diethylstilbestrol

  • Benzo[a]pyrene

  • Nocodazole

  • Cytochalasin

  • DNA damage

  • Zinc deficiency

  • SAC activation
MII oocyte ND ND

  • Emi2

  • Gas6

  • Ccnb1

  • Obox4

  • Spin1

  • UBE2S

  • GPR3

  • EMI2

 ND ND

  • Paclitaxel

 ND