Figure 6.

CircPVT1 negatively targets miR-124-3p.

Notes: qRT-PCR detected the expression of miR-124-3p in LA tissues and adjacent tumor tissues from 60 LA patients (A) and in macrophages after transfection (B) (n = 3). The binding of miR-124-3p and circPVT1 in the 3ʹUTR region was predicted by TargetScan (C). The dual-luciferase reporter assay was used to verify the binding relationship between miR-124-3p and circPVT1 (D) (n = 3); **P < 0.01, compared to the Normal group or the mimic+mut-circPVT1 group; *P < 0.05, ***P < 0.001, compared to the si-NC group, inhibitor NC group or si-circPVT1 group; LA, lung adenocarcinoma.