Figure 3.

T. brucei TryS hit compounds from the ENAMINE library. CPA: carboxy piperidine amide derivatives, AMTPh: amide methylene thiazole phenyl derivatives, AMPh: amide methylene phenyl derivatives and singleton: 17, the most potent singleton with its adamantine moiety highlighted in orange. The scaffolds or moiety of interest are highlighted in different bold colours. The EC₅₀ (bloodstream T. brucei) and selectivity index (value in brackets, reference cell line: human macrophages, THP-1) are shown only for compounds with anti-proliferative action against T. brucei at concentrations ≤25 µM. All the errors are expressed as one SD and the compounds’ molecular mass in Daltons.