Table 1.
Clinical characteristics of a pediatric patient with IgAN flare following COVID-19 vaccination.
| Variables (reference range) | After COVID-19 vaccination | Variables (reference range) | After COVID-19 vaccination |
|---|---|---|---|
| Clinical symptoms/signs on admission |
Fever | Sodium (serum) (133–150 mmol/l) | Day 2: 140 |
| Fatigue | Day 3: 140 | ||
| Swelling and pain at injection site | Day 5: 137 | ||
| New-onset macroscopic hematuria (dark red) 4 times daily | Day 7: 138 | ||
| Stage I hypertension | 4 days post discharge: 137 | ||
| Antineutrophil cytoplasmic antibodies (ANCA-ELISA) Positive: >5.0 | Day 2: cANCA: 2.5 | Potassium (serum) (3.5–5.3 mmol/l) | Day 2: 3.78 |
| Day 2: pANCA: 1.5 | Day 3: 4.05 | ||
| Total Protein (serum) (6–8 g/dl) | Day 2: 7.2 | Day 4: 4.87 | |
| Albumin (serum) (3.8–5.4 g/dl) | Day 2: 4.1 | Day 5: 4.64 | |
| Complement 3 (serum) (90–180 mg/dl) | Day 2: 137 | Day 7: 4.26 | |
| Complement 4 (serum) (10–40 mg/dl) | Day 2: 21 | 4 days post discharge: 4.89 | |
| Anti-streptolysin O Titer (<200 IU/ml) | Day 2: 47 | Chloride (serum) (98–111 mmol/l) | Day 2: 103.6 |
| Antinuclear antibodies (ANA abnormal > 1.2) | Day 2: 0.4 | Day 3: 105.8 | |
| C-Reactive Protein (0.1–2.8 mg/dl) | Day 2: 51.23 | Day 5: 105.7 | |
| Urea (serum) (15–36 mg/dl) | Day 2: 61 | Day 7: 101.5 | |
| Day 3: 62 | 4 days post discharge: 100.2 | ||
| Day 4: 88 | |||
| Day 5: 91 | Calcium (serum) (8.8–10.8 mg/dl) | Day 2: 9.5 | |
| Day 7: 68 | Day 3: 9.73 | ||
| 4 days post discharge: 65 | Day 4: 10.3 | ||
| Creatinine (serum) (0.53–0.79 mg/dl) | Day 2: 1.77 | Day 5: 9.67 | |
| Day 3: 1.74 | Day 7: 9.96 | ||
| Day 4: 1.59 | 4 days post discharge: 9.66 | ||
| Day 5: 1.39 | Phosphorus (serum) (4–7 mg/dl) | Day 2: 5.03 | |
| Day 7: 1.39 | Day 3: 5.87 | ||
| 4 days post discharge: 0.87 | Day 4: 5.87 | ||
| Uric acid (serum) (3.5–7.2 mg/dl) | Day 2: 6.3 | Day 5: 5.02 | |
| Day 3: 6.0 | Day 7: 5.72 | ||
| Day 4: 6.2 | 4 days post discharge: 3.22 | ||
| Day 5: 5.1 | Urine analysis | Day 2: Dark red, Turbid appearance, Heavy proteinuria (1.7 g/l), WBC: 16/ul (up to 5), RBC: 1920/ul (up to 2) |
|
| Day 7: 5.1 | Day 7: Yellow colour, Hazy appearance, Trace protein, WBC: 22/ul (up to 5), RBC: 254/ul (up to 2) |
||
| 4 days post discharge: 3.6 | Four days post discharge: Yellow colour, Hazy appearance, Trace protein, WBC: 10/ul (up to 5), RBC: 992/ul (up to 2) |
||
| Bicarbonate (serum) (20–28 mmol/l) | Day 2: 20.5 | ||
| Day 3: 19.1 | |||
| Day 4: 16.5 | |||
| Day 5: 18.4 | |||
| Day 7: 22.2 | |||
| 4 days post discharge: 137 |